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Abstract          Objective: Recently there is increased incidence of Dengue fever in urban as well as rural area which is associated with loss of working days, morbidity and mortality. There are generalized misconceptions about thrombocytopenia-platelet transfusion-outcome of disease. Hence we decided to take this study. Materials and Methods: A prospective study was conducted in our hospital in medicine department from 1st Jan2012 to 31st Dec 2012. Various factors like age, symptoms, hematocrit, platelet count, liver and renal function tests, third space loss, presence or absence of shock, outcome in relation to shock and platelet transfusion were studied independently and in association with each other. Data was collected, tabulated and analyzed. Results: Presence of shock at time of admission was an important factor contributing to hemorrhage in Dengue Hemorrhagic Fever. No association between platelet count and hematocrit at time of admission and outcome of the disease. Insignificant P value(0.129) for platelet transfusion and overall outcome in patients. Positive association of shock with third space loss of fluid. Significant association of shock with mortality. Conclusion: Main factor contributing to mortality was presence of shock, hence shock should be corrected rapidly with careful I.V. administration to prevent tissue hypoxia and organ dysfunction. Platelet count does not correlate with severity and mortality of the disease. Prophylactic transfusions are unnecessary. Platelet transfusion may benefit the patient with thrombocytopenia and hemorrhage which continues despite blood transfusion.

Keywords: dengue fever, thrombocytopenia.



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