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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 2, June 2014 pp 241-244

Research Article

A comparative study of biochemical markers of renal function and creatinine clearance in hypertensive and normotensive males

Divya R.1, Chandra S.2, Ashok V.3

1Postgraduate student, 2Professor and HOD, Department of Physiology, SMVMCH, Puducherry, INDIA.

3Postgraduate student, Department of Biochemistry, SMVMCH, Puducherry, INDIA.

Academic Editor: Dr. Aher K. R.



Introduction: Hypertension is the most common cardiovascular disease all over the world. Hypertension and renal function are closely related. Glomerular filtration rate is the best estimate of number of functioning nephrons and functional renal mass. Accurate measure of GFR is time consuming and expensive, but a number of filtered substances (blood urea, serum creatinine, uric acid) may be measured to estimate GFR. The aim of the study is to compare the renal function tests and creatinine clearance in hypertensive and normotensive males. Materials and Methods: Study setting: a hospital based case control study done by Department of Physiology, Sri Manakula Vinayagar medical college hospital Madagadipet, Puducherry. Sample size for study was calculated to be 100 with case control ratio being 1:1. Biochemical markers of renal function were calculated to test the significance of renal function among hypertensive’s and normotensives. Data was entered and analysed using SPSS version16. Results: Renal function tests were significantly elevated in hypertensive’s when compared to normotensives whose p<0.05; urea 0.048, creatinine 0.000, uric acid 0.009, whereas creatinine clearance is not significantly elevated, p 0.362(p>0.05) which implies creatinine clearance is not found to be a significant indicator of renal function among hypertensives. Conclusion: The present study shows that elevated urea, creatinine, uric acid are strong predictor of renal impairment among hypertensives. Creatinine clearance does not appear to be a significant indicator for renal impairment among hypertensives in the present study.