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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 139-143

Research Article

High Sensitive C Reactive Protein in Diabetes Patients and its Correlation with Glycaemic Control

Venkateshwarlu Nandyala¹, Gandiah P.², Srinivas Pallerla³

Sivarajappa P.⁴, Krishnaprasad T.⁵, Karthik R. S.⁶

{^1,4Professor, ²Professor and HOD, ^3,6Ex-PG Student, Assistant Professor}

Academic Editor : Dr. Aher K.R.

Background: High sensive C reactive protein (hs–CRP) is found to be significant in people with diabetes. Hyperglycaemia is an associated factor to the increase of serum CRP levels.Materials and methods: The study conducted at SVS Medical College and Hospital, Mahabubnagar from August 2008 to July 2011. The subjects were the 200 randomly selected patients attending and/ or admitted to Medicine Out-patient and In-patient departments plus 100 age and sex matched healthy volunteers. Anthropometric measurements apartment blood sugars, blood urea, serum Creatinine, serum uric acid, and lipid profile and hs-CRP done in all 300 cases. .Data analyzed and statistically significance was sought.Observations: In comparison with non-diabetic subjects, the diabetic subjects were older (P < 0.008) and had higher BMI (P<0.006). They also had higher systolic blood pressure (P<0.05) and diastolic pressure blood pressure (P<0.05), fasting blood sugar (P<0.0018), post prandial blood sugar (P<0.0016) HbA1C % (P<0.001). hs-CRP levels were significantly higher among the male diabetic subjects with 4.88 ± 2.02 mg/L (P<0.05); the female diabetic patients showed levels of hs-CRP as 5.12 ± 2.14 mg/L for non-diabetic subjects with 1.24 ± 0.56mg/L. Discussion and conclusions: Anthropometric parameters were found to be high in diabetic subjects compared with non-diabetic subjects. The high hs-CRP levels in diabetic subjects were observed. Literature was reviewed accordingly. The results concluded that hs-CRP has strong association with diabetic individuals. The significance of hs-CRP in diabetic and non diabetic individuals was discussed.