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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 9, Issue 3, January 2014 pp 328-331

Research Article

Evaluation of Cardiovascular Risk Factors in Psoriasis Patients

Aliya Nusrath¹, Prathibha K.², Rajeshwari A.³

¹Professor and HOD, ²Post graduate, ³Associate Professor, Department of Biochemistry

Academic Editor : Dr. Aher K.R.

Background and Objective: Psoriasis is a common chronic and recurrent inflammatory skin disorder that has been associated with oxidative stress, abnormal plasma lipid metabolism and with high frequency of cardiovascular events. The aim of our work was to evaluate the cardiovascular risk factors such as oxidative stress and dyslipidemia in psoriatic patients. Methodology: Fifty psoriasis patients and fifty control subjects were included for the study. We estimated lipid profile by using auto analyser EM 200 and MDA (malondialdehyde) levels by thiobarbituric acid method. Statistical analysis was done by student ‘t’ test. Results and Conclusion: Patients presented cardiovascular disease risk changes in lipid profile (increase in triglycerides (p=0.002), low density lipoprotein cholesterol (p=0.002), very low density levels (p=0.002) and a reduction in high density lipoprotein cholesterol (p<0.001)) which were highly significant when compared to controls, and increase in MDA levels which were statistically highly significant (p<0.001) when compared to controls. Our data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease.