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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 4, Issue 1, 2012 pp 41-44

Research Article

Efficacy of Saccharomyces boulardii strain in acute diarrhoea in children: An Indian Perspective
Meeta A. Burande1*, Amit R. Burande2
{1Department of Pharmacology, 2Department of Anatomy} D Y Patil Medical College, D Y Patil University, Kolhapur (MS) INDIA.
Academic Editor:  Dr. Aher K.R.


Context: There are different probiotic preparations are available in Indian market, but the efficacy & superiority over each other or ORS & zinc only is not established with certainty. At the same time whatever information is available none is conducted over Indian children so far. Hence, there is a need to study the efficacy of Saccharomyces boulardii in diarrhoea in Indian children. Aims: To compare the efficacy of ORS + Zn verses ORS + Zn + Probiotics Saccharomyces boulardii strain in treatment of acute diarrhoea in Indian children. Settings and Design: prospective, parallel, single blind randomized controlled clinical trial in Hospital attached with Medical College. Methods and Material: 75 children up to 5 years of age suffering from acute diarrhoea (three or more unformed stools within last 24 hrs) of less than 48 hours with CBC and stool microscopy negative for infection. All children were given ORS ad lib till resolution of diarrhoea and Zinc 10 mg per day in child of less than 6 month and 20 mg per day for child above 6 month a day for 14 days. While intervention arm (n=35) were also given Saccharomyces Boulardii 250 mg orally two times a day for 5 days. Main Outcomes Measured were duration of diarrhoea and duration of vomiting in days. Statistical analysis used: Z test and student t test Results: Mean duration of diarrhoea for study group was 3.4 days + 1.4 days and for control group was 5.5 days + 2.1 days (Z value 4.9). Average time of recovery from vomiting was 2.5 +1.2 days for study group & for control were 3.3 + 1.2 days (t17 = 3.3, P< 0.01). Conclusions: Saccharomyces boulardii in the treatment of acute diarrhoea significantly reduces the duration of diarrhoea as well as vomiting