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International Journal of Recent Trends in Science and Technology, E-ISSN: 2249-8109

 Volume 1, Issue 3, 2011 pp 104-109

Date of Publish: 07 December 2011

Research Article

Neonatal Screening for Sickle Cell Disorders

R. D. Hanmante¹, S. W. Chopade², K. S. Dhumure², S. Shere³, R. S. Bindu⁴

¹Assistant Professor, Dept. of Pathology, Dr Shankarrao  Chavan Govt. Medical College, Nanded (MS) INDIA.

²Resident, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

³Assistant Professor, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

⁴Professor & Head, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

Academic Editor:  Dr. Pawar D.D.

500 newborns (age group 0 � 1 month) were screened using the sickle cell short programme kit by HPLC. First the blood samples of newborns were subjected for CBC. The neonates having low haemoglobin content [i.e. Hb < 14 gm %] were subjected for High Performance Liquid Chromatography (HPLC) study.  Out of 500 newborns, 8 (1.6%) cases were sickle cell trait with male 6 (75%) preponderance with the more common clinical presentation of fever. Sickle cell trait was more prevalent in Bouddha 3 (37.5%) community followed by Muslim 2 (25%) and Matang 2 (25%). Hb S gene is also found in Banjara community 1 (12.5%).