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International Journal of Recent Trends in Science and Technology, E-ISSN: 2249-8109

 

 Volume 1, Issue 3, 2011 pp 104-109

 

Date of Publish: 07 December 2011

 

Research Article

 

Neonatal Screening for Sickle Cell Disorders

R. D. Hanmante1, S. W. Chopade2, K. S. Dhumure2, S. Shere3, R. S. Bindu4

1Assistant Professor, Dept. of Pathology, Dr Shankarrao  Chavan Govt. Medical College, Nanded (MS) INDIA.

2Resident, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

3Assistant Professor, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

4Professor & Head, Dept. of Pathology, Govt. Medical College, Aurangabad (MS) INDIA.

Academic Editor:  Dr. Pawar D.D.

Abstract

500 newborns (age group 0 1 month) were screened using the sickle cell short programme kit by HPLC. First the blood samples of newborns were subjected for CBC. The neonates having low haemoglobin content [i.e. Hb < 14 gm %] were subjected for High Performance Liquid Chromatography (HPLC) study.  Out of 500 newborns, 8 (1.6%) cases were sickle cell trait with male 6 (75%) preponderance with the more common clinical presentation of fever. Sickle cell trait was more prevalent in Bouddha 3 (37.5%) community followed by Muslim 2 (25%) and Matang 2 (25%). Hb S gene is also found in Banjara community 1 (12.5%).