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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 82-84

Research Article

Hematological Profile in Patients of Sickle Cell Anemia and Sickle Cell Trait in Relation to Blood Gas Analysis—Revisited

 

Kulkarni R. A.1, Gangane N.2, Sharma S. M.3

1Assistant Professor, Department of Pathology, Walawalkar Medical College and Hospital, Dervan, Ratnagiri, Maharashtra, INDIA.

2Professor, 3Professor, Department of Pathology, MGIMS, Sewagram, Maharashtra, INDIA.

 


Academic Editor : Dr. Aher K.R.

Abstract

 

Several works in different parts of the world have contributed to the etiological and hematological aspects of sickling disorders. The work in this study was planned to correlate hematological profile with blood gas analysis in cases of sickle cell anemia and sickle cell trait .Sickling disorders are associated with an abnormal hemoglobin, vascular obstruction by sickled cells and a resultant shunting of blood across the pulmonary circulation without access to ventilation. An important aspect of the pathophysiology of sickling disorders lies in the maintenance of adequate oxygen delivery in the face of anemia and vascular obstruction, confounded by compensated pulmonary function. Some of the contemporary works on pulse oximetry have thrown light on various other parameters that need to be considered.