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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 104-107

Research Article

PMNL Status in Type-II Diabetic Patients with Multi-Vitamin Multi-Mineral Supplementation

 Bhushan Mahajan¹, S. K. B. Patil², Manohar Muddeshwar³

{¹Assistant Professor, ³Professor and Head}

Department of Biochemistry, Government Medical College and Hospital Nagpur, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.

Introduction: We have studied the effect of multi-vitamin multi-mineral supplementation on polymorphonuclear leukocyte(PMNL) membrane status in Type II Diabetes Mellitus patients.Material and Methods: The study was divided into four groups. Group A- Diabetic patients (DM0). Group B consisted of normal healthy controls (NHC), Group C of Diabetic patients given multi-vitamin multi-mineral supplementation capsules for 30 days (DM30). Group D consisted of diabetics withdrawn from multi-vitamin multi-mineral supplementation for next 30 days (DM60). Fasting blood samples were collected from the respective groups. PMNL Phospholipid phosphorous (PLp), cholesterol, triglyceride lipase, triglycerides, vitamin C, Magnesium and Zinc were estimated by standard methods. Analysis of variance was calculated by applying students “t” test.Results and discussion:- The PMNL cholesterol, triglycerides, phospholipids phosphorous were significantly high (p<0.05) whereas PMNL triglyceride lipase, vitamin C, Zinc and magnesium were significantly low (p<0.05) in DM without multi-vitamin multi-mineral supplementation as compared to NHC . The levels of Cholesterol, triglycerides, Phospholipid phosphorus significantly decreased after 30 days supplementation. Withdrawal of supplementation for next 30 days showed a slight increase in PMNL PLp. A significant increase in PMNL TG lipase activity was seen after multi-vitamin multi-mineral supplementation in diabetic patients. Supplementation of multi-vitamin multi-mineral capsules to diabetic patients showed significant elevation in PMNL Vitamin C, PMNL Mg and PMNL Zn. A significant change was observed in the levels of PMNL Vitamin C, Mg and Zn after withdrawing multi-vitamin multi-mineral supplementation for next 30 days.Conclusion:-This suggests that multi-mineral multi-vitamin supplementation in combination with conventional hypoglycemic treatment may modulate the PMNL function and provide better metabolic control in Type II Diabetes Mellitus patients.