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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 191-193

Research Article

Analysis of Endometrial Hyperplasia in Perimenopausal Uterine Bleeding with Evaluation of Uterine and Ovarian Changes


Shazia Anjum1, Suresh Gawai1, Rekha Mudkhedkar2, Padma Bakal3, Bindu RS5, Badaam Khaled M5, Bhople KS6

{1Assistant Professor, 4Professor and Head, Department of Pathology}{5Assistant Professor, Department of Physiology}{6Dean}

Government Medical College, Aurangabad, Maharashtra, INDIA.

2Pathologist, Civil Hospital, Jalna, Maharashtra, INDIA.

3Pathologist, Civil Hospital, Nashik, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.



Introduction: Abnormal Uterine Bleeding (AUB) is among the most common health problems encountered by women especially in perimenopausal period. Chronic anovulation can lead to irregular bleeding, prolonged unopposed oestrogen stimulation of the endometrium, and increased risk of endometrial cancer. Methods: Total 200 cases of perimenopausal uterine bleeding in women above 40 years of age were studied with reference to endometrial hyperplasia. 110 Endometrial samples were obtained from Dilatation and Curettage and 90 samples from hysterectomy cases. Uterine and ovarian changes were observed in the 90 samples from hysterectomy cases. Results: Endometrial Hyperplasia was observed in 32 (16%) cases. Out of these 32 cases of hyperplasia, most of the cases i.e. 27 (84.37%) had simple type of hyperplasia, followed by 3 cases (9.37%) of complex hyperplasia. Atypical hyperplasia was found in 2 (6.25%) cases. Endometrial malignancy was detected in 2% of the total cases and all were endometrial adenocarcinoma. Associated changes in uterus observed among the 90 samples of hysterectomy were chronic cervicitis in 31 cases, Adenomyosis in 21 cases, Leiomyoma in 21 cases and Leiomyomatous polyp in 3 cases. Out of 90 hysterectomy specimens, 22 ovaries showed pathological lesion. Eleven ovaries showed follicular cyst, in four cases corpus luteum was seen, five ovaries showed epithelial tumours, Granulosa cell tumour of ovary was found in one case and a single case of fibroma of ovary was observed. Conclusion: Histopathological study of endometrium in females with abnormal uterine bleeding plays an important role in diagnosing various histological patterns. Endometrial hyperplasia can be evaluated for early detection of cancer endometrium which has excellent prognosis if detected in bud. Chronic cervicitis was the most common associated uterine change found in perimenopausal bleeding whereas ovarian pathology was also found in significant cases.