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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 26-27

Research Article

Evaluation of Hypoglycemic Activity of Tramadol in Streptozotocin Induced Diabetic Rats


Totagi Vinod Gangadhar1*, A. M. Satish2, M. K. Jayanthi3, M. Brahadeesh4, Lokraj Subedee5

Suresha R. N.6

1Post graduate student, 2Associate Professor, 3Professor and HOD, 4Post graduate Student, 5M.Sc. Post Graduate Student, 6Professor

Department of Pharmacology, JSS Medical College(A Constituent College of JSS University, Mysore)SS Nagar. Mysore, Karnataka, INDIA.


Academic Editor : Dr. Aher K.R.



Objective: To evaluate the hypoglycemic activity of Tramadol in streptozocin induced diabetic rats. Methods: In this study, 18 albino rats (Three groups each containing six rats)were included for the study. After 4 days of streptozocin injection those rats that develop fasting blood sugar >200mg/dl will be selected for the study. The study groups will be divided as follows, Group-1 (CONTROL): Distilled water 0.5ml (oral), Group-2 (STANDARD): Streptozocin (60mg/kg) i.v. and Group-3 (TEST): Streptozocin(60mg/kg) i.v.+ Tramadol(0.45mg/kg). Fasting blood glucose levels from experimental animals will be measured on 1, 3, 7, 14 and 28th day by capillary blood glucose method by using glucometer(ACUCHEK). Results: In this study after inducing diabetes with streptozotocin(60mg/kg) diabetes was induced and test drug has showed significant hypoglycemic activity comparing to standard drug Glimepiride.