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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 1, February 2014 pp 32-35

Research Article

Correlation of Blood Glucose Level with Working and Short Term Memory Status in Type 2 Diabetes Mellitus

Sanjay B Bhagoji^1*, Mrutyanjay Mirje², Mahesh Patil³, Mallikarjun Biradar⁴

¹Assistant Professor, Department of Physiology, K.V.G Medical College and Hospital, Kurunjibhag, Sullia, Karnataka, INDIA.

²Department of Pharmacology, Institute of Medical Science and Research, Mayni, Satara-415102, Maharashtra, INDIA.

³Deparment of Pathology, B.K.L Walawalkar Hospital Research and Diagnostic Centre, dervan, Ratnagiri, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.

Background and Objectives: Working and short term memory loss is common in poorly controlled diabetic patients. Though cognitive deficits affect daily activities much importance is not given to assess working and short term memory at bedside. Hence this study was undertaken to correlate blood glucose level with working and short term memory in type 2 diabetics compared with age and gender matched normal subjects. Methodology: Present study was conducted in Al-Ameen Medical College and Government district Hospital, Bijapur on 114 diabetics aged (40-60 yrs.) and 119 normal subjects aged (40-60 yrs.). Cognitive function assessment was done for short term and working memory by using 5 memory tests. For short term memory- AVLT, VFT and VRT and for working memory – WDST and VST were used. The results were expressed in average total scores(%). T test and Correlation-regression analysis were used for statistical analysis. Results: Significant decrease in working and short term memory was observed in diabetic patients. In diabetes patients mean FBS was found to be 146+29.2mg% compared to the mean FBS levels of normal subjects (97.9+12.6mg %). In diabetes patients mean PPBS was found to be 194+39mg % compared to the mean PPBS levels of normal subjects (133+11.1mg %). Memory scores in all 5 tests were found to be decreased correlating negatively with the FBS and PPBS levels. Interpretation and Conclusion: The short term and working memory status in the present study decreased significantly in the diabetic patients, which may be due to hyperglycemia, hypoglycemia, vascular dementia and insulin resistance. Therefore these observed effects of FBS and PPBS levels are of potential clinical importance because working and short term memory loss could interfere with day today activities.