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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 2, March 2014 pp 196-201

Research Article

A Prospective, Randomized, Open-label, Comparative Study between Amlodipine and Diltiazem in Non-diabetic Patients of Mild to Moderate Hypertension


Santosh C. Gursale1, Sudheer Kumar2, Narayan P. Burte3, Mohankrishna Ghanta4

1Professor and Head, Department of Pharmacology, I.M.S.R. Mayani, Satara, Maharashtra, INDIA.

3Professor and Head, 2,4M. Sc. P. G. Student, Department of Pharmacology, M.N.R. Medical College, Sangareddy, Andhra Pradesh, INDIA.


Academic Editor : Dr. Aher K.R.



 Introduction: In developed countries hypertension is held responsible a fourth contributor to premature death, while it ranks seventh in developing countries. It is important to know this fact because even a 2 mmHg decrease can prevent 151,000 stroke and 153,000 coronary heart disease deaths in our country.Ca2+ channel blockers are effective and preferred drugs in lowering blood pressure and decreasing cardiovascular events in the elderly with isolated systolic hypertension. It is therefore imperative that we should have maximum data on their pattern of utilization and the adverse drug reactions.Aims and Objective: To observe and compare the anti-hypertensive efficacy as well as incidence of adverse drug reactions between amlodipine anddiltiazem.Materials and Methods: This prospective, comparative, open-label study included 80 patients suffering from stage I / II essential hypertension. These patients included males and females randomized in each study group. Observation and Result: In the present study, we observed that amlodipine anddiltiazem are effective agents in reducing both systolic and diastolic BP throughout the study period when measured at the 15thday, 30thday, 45thday and 90th day. A total of 39% of the patients reported some sort of adverse-effects like peripheral oedema (12.5%), nausea(5%), dizziness (5%), headache (7.5%) and , abdominal pain (2.5%) in the group1 and 24% in the diltiazem treated group 2, with noted adverse-effects like peripheral oedema (5%), nausea (5%), dizziness (5%), headache (5%) and abdominal pain (0%). Conclusion: The antihypertensive effect of these two drugs included in the study was statistically significant. These two drugs were equally effective in reducing the systolic and diastolic blood pressure. The incidence of peripheral oedema, abdominal pain and headache were more in amlodipine treated group than diltiazem treated group. However, this difference in the frequency of adverse-effects between the two groups was not statistically significant (P > 0.05). Adverse effects were tolerated by both the study groups and hence can be used as efficient antihypertensive drugs in management of essential hypertension.