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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 2, March 2014 pp 373-377

Research Article

Clinical and Laboratory Parameters Differentiating Dengue from Other Causes of Acute Febrile Illnesses in A Tertiary Care Centre in South India


Yogeesha K. S.1, Sreejith M. G.2, Raghavendra Bakki Sannegowda3, Manjunath J.4, Arunachalam R.5

{1Assistant Professor, 2PG Student, 5Professor, Department of Medicine} {3Assistant Professor, Department of Neurology}

{4Assistant Professor, Department of Nephrology} Father Muller Medical College Hospital, Mangalore, Karnataka, INDIA.

Academic Editor : Dr. Aher K. R.


Aims: To study the utility of clinic-laboratory parameters in differentiating dengue fever from other common causes of acute febrile illness with thrombocytopenia. Material and methods: This is a retrospective study conducted in patients, admitted to a tertiary care facility in South India between 1rst June & 31rst December 2012, with the diagnosis acute febrile illnesses with thrombocytopenia like Dengue fever (DF), malaria, leptospirosis, viral infections and typhoid fever. Their clinical and laboratory parameters were compared for the diagnostic utility in acute febrile illness with thrombocytopenia. Results: Out of  200 cases were collected for the entire study 80 cases were dengue positive, 70 cases were malaria positive, 25 cases were IGM  Leptospira positive,  20 cases were diagnosed as viral fever and 5 cases were diagnosed as typhoid based on widal and blood culture. Among the total 200 cases 110 were males and 90 were females. The most common age group affected in our study was 20-40 years of age. Malaria usually presented with fever with chills (100%) associated with headache(72.85%), myalgia(55.72%) and nausea/vomiting(62.85%). In Leptospirosis the common manifestations are fever followed by severe myalgia associated with headache, join pain and bleeding manifestations. But the chance of developing complications like thrombocytopenia, bleeding manifestations and renal failure/MODS were high (36%). Among 80 cases of dengue fever 45 were positive for leucopenia(56.25%) and 69 were positive for thrombocytopenia(86.25%) and most of them showing anicteric hepatitis(67.5%). In malaria out of 70 cases 49(70%) were showed features of thrombocytopenia and leucopenia was present in 34 cases and it also showed icteric hepatitis. In leptospirosis most of them showed leucocytosis (24 out of 25) with thrombocytopenia and icteric hepatits and elevated renal parameters. Conclusion: Thorough clinical and laboratory evaluation would be helpful to evaluate different causes of fever with thrombocytopenia and they may replace the need of costly serological investigations in diagnosis.