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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 3, April 2014 pp 451-455

Research Article

The Bacterial Profile and Antibiogram of Neonatal Septicaemia in a Tertiary Care Hospital


D. E. Premalatha1, Mallikarjun Koppad2, L. H. Halesh3, K.C. Siddesh4, N. Prakash5

{1,2,5 Assistant Professor, 3Professor and HOD, 4Associate Professor}

Department of Microbiology, Shimoga Institute of Medical Sciences, Shimoga-577201, Karnataka, INDIA.

Academic Editor : Dr. Aher K.R.



 Background: Neonatal septicaemia is a clinical syndrome of bacteraemia characterized by systemic signs and symptoms in first month of life. The type and pattern of organisms that cause neonatal sepsis changes over time and vary from one hospital to another hospital, even in the same country. Early diagnosis and proper management of neonatal septicaemia can bring down the morbidity and mortality substantially. Objectives: 1) to isolate and identify the bacterial etiologic agents responsible for neonatal sepsis. 2) To compare and contrast the prevalent bacterial pathogens isolated from early onset neonatal sepsis (EOS) and late onset neonatal sepsis (LOS). 3) To access risk factors associated with neonatal sepsis. 4) To determine the susceptibility pattern of isolates to the commonly used antimicrobial agents in the treatment of sepsis. Methodology: Blood culture reports were studied in 306 cases of clinically suspected septicemia in neonates using the standard technique of Mackie and McCartney. The antibiotic sensitivity was performed by Kirby-Bauer's disc diffusion method. Risk factors for sepsis in the children as well as mothers were registered. Results: Blood culture reports were positive in 82.35% of cases. Thirty three babies (79%) had early onset sepsis and 9 (21%) had late onset sepsis. Klebsiella pneumoniae and CNS were the commonest organisms causing neonatal sepsis in both EOS and LOS. Prematurity, lbw and respiratory distress syndrome were strongly associated with blood culture proven neonatal sepsis. Maternal risk factors identified were preterm labour, PROM and intrapartum fever. Conclusion: The spectrum of organisms that cause neonatal sepsis changes over time and varies from region to region. These organisms have also developed increasing multi-drug resistance over the last two decades. Therefore knowledge of the pattern of bacterial isolates and their antimicrobial susceptibility pattern is useful for prompt treatment of patients.