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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 10, Issue 3, April 2014 pp 508-513

Research Article

Predisposing Risk Factors for Neonatal Seizures in Low Birth Weight Babies: Case Control Study

Uday C. Rajput¹, L. S. Deshmukh²

¹Assistant Professor, Department of Pediatrics, Government Medical College Miraj, Maharashtra, INDIA.

²Professor, In-charge, Neonatal Unit, Government Medical College, Aurangabad, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.

Objective: To study the predisposing risk factors for neonatal seizures in low birth weight babies. Design: Prospective case control study. Settings: Neonatology Unit at tertiary care hospital. Outcome measures: Association of risk factors like preconceptional, postconceptional, antepartum, intrapartumand neonatal with neonatal seizures in low birth weight babies. Results:680 low birth weight neonatal babies were divided into two groups,340 low birth weight babies with neonatal seizures served as cases , 340 low birth weight babies matched for gestation, weight and sex without any seizures served as controls. Gestational age group of 34-37 weeks and birth weight between 1500-1750 gms had highest frequency of seizures 39.83% and27.80%respectively.All pre-conceptional factors, consanguinity, maternal height < 140 cm, maternal weight < 40 kg were significant risk factors for neonatal seizures. Unregistered/unbooked pregnancies, pre-eclampsia, eclampsia and maternal anemia were significant risk factors for neonatal seizures. Antenatal factors, magnesium sulphate to mother and maternal fever were significantly associated with neonatal seizures except premature rupture of membrane (p>0.05) and general anaesthesia (p>0.05).All intranatal factors were significantly associated with risk of neonatal seizures except cephalic, non-cephalic presentation (p>0.05) and induced vaginal delivery (p>0.05).All neonatal factors were significantly associated with risk of neonatal seizures except for sex, SGA and sepsis (p>0.05). Conclusion: We conclude that having the knowledge of these factors will help in careful monitoring for occurrence of seizures in low birth weight babies and proper early treatment. This will also help in reducing neonatal mortality.