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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 1, May 2014 pp 51-55

Research Article

Association of Serum Apolipoprotein in Patients with Coronary Heart Disease –

An Observational Study


Deepak Kishan Bokankar1, Kedar Balwant Joshi2, Patil V. P.3

1Associate Professor, Department of Biochemistry, Indian Institute of Medical Science and Research, Badnapur, Jalna, Maharashtra, INDIA.

2Assistant Professor, Department of Biochemistry, Govt. Medical College, Aurangabad, Maharashtra, INDIA.

3Ex. Dean, Government Medical College, Aurangabad, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.



Introduction: Incidence of coronary heart disease (CHD) has shown an upward trend in Indian in the last decade. Estimation of serum lipids like Cholesterol and triglycerides were used to assess the risk of CHD. However, the correlation between serum Cholesterol and CHD is not ideal. Apoplipoprotein play an important role in many disorders of lipid metabolism. Indeed, it has become increasingly clear that while the lipids in lipoproteins are the transported moieties, the protein moieties of lipoproteins - the apoproteins - perform the crucial roles of transporting the lipids, and apoproteins can determine the levels of lipoprotein lipids. Therefore, attempts have been made to assess the relationships between plasma apoprotein concentrations and CHD. Aim and Objectives: To see the association of serum apolipoprotein A-I and B in patient with Coronary Heart Disease. Materials and Methods: The present study was conducted at Government Medical College and Hospital, Aurangabad. Levels of Apolipoprotein A-I and B in 60 Coronary Heart Disease patients admitted with first episode of coronary heart disease in ICCU were compared with 60 healthy apparently normal age, sex matched individuals. Results: it was observed that levels of apolipoprotein A-I and the ratio of apolipoprotein A-1 and B were decreased in CHD patients where as levels of apolipoprotein B was increased in CHD patients as compared to control group. And the difference was also statistically significant. Conclusion: concentration of apo A-I, apo B and its ratio can be a useful summary index of risk of CHD.