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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 1, May 2014 pp 70-72

Research Article

A Comparative Study of Lipoprotein Levels in Normal and Hypothyroidism Patients


Kedar Joshi1, Deepak K. Bokankar2, Hardas V. M.3

1Assistant Professor, 3Associate Professor, Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, INDIA.

1Associate Professor, Department of Biochemistry, Indian Institute of Medical Science and Research, Badnapur, Jalna, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.



Introduction: Thyroid hormones influence all the major metabolic pathways. Their most obvious and well known action is increase in basal energy expenditure obtained acting on protein, carbohydrate and lipid metabolism. With specific regards to lipids, thyroid hormone affects synthesis, mobilization and degradation of lipids, although degradation is influenced more than synthesis.Aims and objectives: To study changes in lipoprotein levels in overt and subclinical hypothyroidism patients and compare it with matched healthy controls in population.Material and method: The present study was conducted in Government Medical College and Hospital, Aurangabad from October 2005 to October 2007. Lipid profile of patients of hypothyroidism was compared with control group. Results: Thus among the patients with overt hypothyroidism, we found highly significant increase in TC, LDL and HDL values and no significant change in TG and VLDL when compared with controls. Among the patients with subclinical hypothyroidism, we found significant increase in TC and LDL while no change in TG, HDL and VLDL when compared with controls.Conclusion: that in overt and subclinical hypothyroidism patients, the lipid profile is clearly atherogenic.