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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 1, May 2014 pp 30-35

Research Article

Analysis of Stevens-Johnson’s Syndrome and Toxic Epidermonecrolysis Patients in a Rural Based Medical College with an Emphasis on Steroid Therapy


Venkateshwarlu Nandyala1, Gandiah P.2, Govind Das3, Harish Kumar J.4, P Anand G. Reddy5,

Sandeep Kumar G.6

{1Professor, 2Professor and HOD, 3Professor and HOD, 4,5,6 P. G. Student}

Department of Internal Medicine, SVS Medical College, Mahabubnagar Andhra Pradesh, INDIA.

Academic Editor : Dr. Aher K.R.



Thirty cases of SJS-TEN were reported during a seven year period between 01-01-2007 and 31-12-2013 were analysed. Eighteen were males, anti-epileptics were the culprits in 11 cases (Phenytoin sodium was responsible in 6, carbamazepine in 4 while sodium valproate was responsible in 1 case. Ofloxacin was responsible in 4 ciprofloxacin and cefixime in one each case whereas another 8 cases it was NSAIDs. Two ayurvedic medications were also noted in our study. 12 patients received 3 days therapy of pulse dose dexamethasone therapy, 6 patients received pulse dose Methyl Prednisolone 7 patients received regular dexamethasone treatment while remaining 5 did not get any steroid. All cases received supportive therapy, barrier nursing and prophylactic antibiotics. Cases who received Pulse dose steroid treatment recovered fast and hospital stay was reduced, while two patients in non-steroid group died and remaining 3 recovered very slowly. Short term (3 days) pulse steroid therapy is well tolerated and recovery is very fast as compared to regular steroid therapy or therapy without steroid. However as the sample size is small we recommend a large study preferably a double blind study.