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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 11, Issue 2, June 2014 pp 127-132
Can apolipoproteins should be consider as better index of risk factor than total cholesterol and traditional lipids?
Deepak Kishan Bokankar1*, Sachin Ashok Patharkar2, Patil V. P.3
1Associate Professor, Department of Biochemistry, Indian Institute of Medical Science and Research, Badnapur, Jalna, Maharashtra, INDIA.
2Assistant Professor, Dept. of Biochemistry, Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, Maharashtra, INDIA.
3Ex. Dean, Government Medical College, Aurangabad, Maharashtra, INDIA.
Academic Editor : Dr. Aher K.R.
Introduction: It is essential to identify and manage risk factors for coronary heart disease in order to prevent its development in asymptomatic individuals (primary prevention) as well as to avoid its recurrence in patients with established disease (secondary prevention). Although low density lipoprotein (LDL) is recognized as the primary lipid related risk factor, and therefore the primary target for lipid lowering therapy, there are in fact several limitations of only using LDL cholesterol as the primary risk variable. New data are accumulating which speak in favor of apolipoproteins as more informative risk indicator/factors. Aims and Objectives: a) To find the relationship between serum Apolipoprotein A-I and B and lipid profile in Coronary Heart Disease patient and age and sex matched healthy control. b) To evaluate, whether Apolipoprotein A-I and B should be consider as better index of risk factor than total Cholesterol or Lipid profile. Materials and methods: The present study was conducted at Government Medical College and Hospital, Aurangabad. Levels of Apolipoprotein A-I and B and lipid profile in 60 Coronary Heart Disease patients admitted with first episode of coronary heart disease in ICCU were compared with 60 healthy apparently normal age, sex matched individuals. Results: It was observed that levels of apolipoprotein A-I and the ratio of apolipoprotein A-1 and B were decreased in CHD patients where as levels of apolipoprotein B was increased in CHD patients as compared to control group. And the difference was also statistically significant. Also lipid profiles in case group showed significant difference as compared to control group except triglyceride and VLDL levels in male group. Conclusion: Levels of serum Apolipoprotein A-I and B and lipid profile in Coronary Heart Disease patient showed significant change as compared to control group. And the concentration of apo A-I, apo B and its ratio can be a useful summary index of risk factor.