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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 11, Issue 2, June 2014 pp 234-237
A study of Apo lipoprotein ‘E’ polymorphism and lipid profile in coronary artery disease
S. M. Mallakmir1*, G. R. Kane1, S. S. Mallakmir2, D. A. Vidhate3, S. Deshpande1, J. Nadkarni4, M. David 4, G. Ravindranathan4, J. Shah4
1Department of Cardiology, 2Clinical Geneticist, 3Department of Biochemistry, Pad. Dr. D.Y. Patil Medical College and Research centre, Nerul, Navi Mumbai, INDIA.
4Department of Biotechnology and Bioinformatics, CBD Belapur, Navi Mumbai, INDIA.
Academic Editor: Dr. Aher K. R.
Apo lipoprotein E (Apo E), a glycoprotein, plays an important role in lipoprotein metabolism. Polymorphism in Apo E genotype affects the clearance of circulatory lipids and leads to dyslipidemia. Association between Apo E polymorphism and risk of coronary artery disease (CAD) has been evident in earlier studies, but its significance has not yet been established. Indian literature in this subject is scant and cultural, ethnic diversity in Indian population can influence the results, hence there is need for more studies in different population groups. We have studied 160 cases during 2009 to 2012, referred to the Department of Cardiology, Dr. D.Y. Patil Hospital and research Centre, Nerul, Navi Mumbai. Lipid profile and Apo E polymorphisms (E2/E3, E3/E3 and E3/E4) were studied in 110 CAD patients and compared them with 50 healthy controls. Conclusions: Our results reported that Apo E3/E4 genotype is one of the most potent genotype associated CAD with abnormal lipid profile.