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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 2, June 2014 pp 159-162

Research Article

Study of influence of thyroid dysfunction on lipid profile

Suryavanshi A. R.¹, Solunke V. N.², Phadnis A. R.³, Kawalkar U. G.⁴, Saple P. P.⁵, Bodhgire S. B.⁶

^1,2,4Assistant Professor, ⁵Professor and Head, ⁶Senior Resident, Department of Pediatrics SRTR GMC Ambajogai, Beed Maharashtra, INDIA.

³RMO, Rural Hospital Indapur, Pune, Maharashtra, INDIA.

Academic Editor : Dr. Aher K.R.
Abstract

Introduction: Thyroid function regulates a wide array of metabolic parameters. Thyroid function significantly affects lipoprotein metabolism as well as some cardiovascular disease (CVD) risk factors, thus influencing overall CDV risk. Aims and objectives: To study changes in lipoprotein levels in hypothyroidism and hyperthyroidism patients and compare it with matched healthy controls in population. Results: In hypothyroidism patients there was decrease in synthesis of cholesterol, serum total and LDL cholesterol levels are increased. In patients with overt hypothyroidism, we found highly significant increase in TC, LDL and HDL values and no significant change in TG and VLDL when compared with controls. Whereas in patients with subclinical hypothyroidism, we found significant increase in TC and LDL while no change in TG, HDL and VLDL when compared with controls. Conclusion: Thyroid dysfunction has influence of on lipid profile. In hypothyroidism, though there was decrease in synthesis of cholesterol, serum total and LDL cholesterol levels are increased. This was mainly due to decrease in LDL catabolism. And in overt and subclinical hypothyroidism patients, the lipid profile is clearly atherogenic.