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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 3, July 2014 pp 359-362

Review Article

A study of effect of highly antiretroviral therapy on immunological profile with special references to pediatric HIV patients

Shakira Vijay Savakar¹, Shivprasad Kachrulal Mundada², Asadkhan Sahebkhan Pathan³,

Pavan Hanumantrao Jadhav⁴

Abstract

Introduction: India harbors world’s second highest number of HIV infected people. HIV infection is increasingly becoming a prominent cause of childhood morbidity and mortality in India. The suppression of immune system primarily affecting cell mediated immunity is hallmark of AIDS. Early diagnosis is important for timely initiation of ART because it is desirable to start treatment before severe immune deficiency. Aims and objectives: to study role of HAART in improvement of immunological profile of paediatric HIV patients. Material and Methods: The present prospective study was carried out in ART Centre and paediatric ward of Government Medical College, Latur. Children with HIV and fulfilling their criteria of starting HAART were followed for one year. And the effect of HAART on the immunological status was observed. Results: Significant improvement in mean CD4 count and CD4% was seen after 6 month and after one year of institution of HAART. Mean CD4 count was increased to 856.4 from 606.8. Conclusion: HAART has defiantly important role in improvement of immunological profile of pediatric HIV patients.