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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 3, July 2014 pp 363-367

Review Article

Understanding of alcoholism induced hepatocellular damage with specific emphasis of selected markers

Praveen Kumar G S^*, Carlos Noel Menezes^#, Meghalatha T S^**

^#Assistant Professor, Department of Biochemistry, Goa Medical College, Bambolim, Tiswadi, Goa, INDIA.
Abstract

Introduction: Liver performs many important functions such as uptake, storage, and disposal of nutrients (protein, glucose and fat), drugs and toxins. The liver is responsible for the elimination of 95% of ingested alcohol through metabolism. Chronic alcohol ingestion causes damage to hepatocytes. Various markers have been stated to be useful to diagnose hepatic damage by alcohol. Aims and Objectives: to study the alcoholism induced hepatocellular damage with specific emphasis of selected markers. Materials and Method: four groups of 10 individuals each were formed. One group was control where as in remaining three alcohol dependent individuals with varying years of chronicity of alcohol consumption were enrolled. Serum GGT, AST, ALT, total protein, albumin, globulin and bilirubin were tested on fasting blood samples of all the study subjects. And were compared. Results: increase in serum GGT was observed in alcoholic and it was increasing proportionally with chronicity of alcohol consumption. Similar trend were also observed i9n serum AST and ALT levels and also with AST:ALT ratio. No major change in protein levels was observed. biliribin levels were increased but they were not increasing with the chronicity of alcohol consumption. Conclusion: combination of serum GGT, AST, ALT and ratio of AST and ALT can be used for diagnosis of alcohol induced hepatocellular damage instead of any single marker.