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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 11, Issue 3, July 2014 pp 386-389

Review Article

Prevalence of extended spectrum beta lactamases producers among surgical wound infections and burns patients at tertiary care hospital, Nanded

Vivek M. Gujar1, Sharmila S. Raut2, Sanjaykumar R. More3

{1Assistant Professor, 2Professor, 3Associate Professor} Department of Microbiology, Dr. S.C. Government Medical College, Nanded, Maharashtra, INDIA.



Introduction: The purpose of this study was to know the prevalence of Extended Spectrum beta lactamases (ESBL) among surgical wound infection and burn patients. Methods: A total of 100 patients admitted to the surgical wards with post operative wound infections and burns from January 2014 to May 2014 were studied.A total of 137 isolates were obtained from these patients.Of these, 87 organisms (63.5% of the total isolates) were found to be Extended Spectrum beta lactamases (ESBL) producers. The commonest were Escherichia coli and Klebsiella pneumonia.  They were studied for ESBL production by screening test, CLSI disc diffusion method and phenotypic confirmation by disc potentiation test. Result: Out of 100 strains, 87 (63.5%) were confirmed as ESBL producers. Among the ESBL producer all the isolates were sensitive to Imipenem. Resistance against Ampicillin (10ug) is 100%, Gentamicin (10ug) is 80.46%, Ciprofloxacin (5ug) is 74.72%, Tetracycline (30ug) is 63.22% and Amikacin (30ug) is 16.10. % Conclusion: Our study shows presence of ESBL producer among surgical wound infections and burn patients and their prevalence is 63.5%. The routine antimicrobial sensitivity test may fail to detect ESBL. Detection of ESBL production should be carried out as a routine in diagnostic laboratories by disc potentiation test as it is a simple and cost effective test. Antibiotics resistance is significantly more prevalent in ESBL positive isolates as compared to ESBL negative.