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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 12, Issue 1, September 2014 pp 91-94

Research Article

Study of relationship between pregnancy induced hypertension and homocysteine

Karunashree1, Bijan Kumar Mukhopadhyay2, K. Gayathri3, Sangeeta Chippa4, N. Bhavani5, Chitra Patil6

1Professor and HOD, Department of Bio-chemistry, MNR Medical College, Medak, Andhra Pradesh, INDIA.

2Senior Resident, Department of Obstetrics and Gynaecology, Community Health Centre, Jogipet Government Hospital, Medak,

Andhra Pradesh, INDIA.

3Consultant, Sangareddy Dist. Hospital, Medak, Andhra Pradesh, INDIA.

4Assistant Professor, 5Associate Professor, 6 Emeritus Professor, Department of Obstetrics and Gynaecology, MNR Medical College, Medak, Andhra Pradesh, INDIA.

Objective: To assess the homocysteine level in pregnancy induced hypertensive patient and also correlate levels of homocysteine in preeclampsia and pregnancy outcome. Method: It is a case control study conducted in antenatal ward at Government maternity hospital, Sultan Bazar. 100 subjects were recruited for study during antenatal period irrespective of gestational age and gravidae, during the year 2007-2008, were taken into the study.50 subjects were included those who fulfilled inclusion criteria. Results: Most of the patients are less than 20 years of age. Most of the patients are in second gravidae. Homocysteine levels are more with patient with second gravidae with diastolic blood pressure more than 100 mm of Hg and also showing significant proteinuria. High homocysteine level with preeclampsia patient have more preterm delivery rate with high caesarean section rate. It also shows some elevation in liver enzyme, in renal parameter and coagulopathy. In baby it was with abnormal non stress test. Most of the babies delivered are IUGR, LBW and preterm. Conclusion: Preeclampsia is a leading cause of maternal and fetal mortality and morbidity.The exact mechanism how Hyperhomocysteinemia promotes endothelial dysfunction remains unclear, but it involve both cytotoxic and oxidative stress mechanism to promote endothelial dysfunction in preeclampsia.Hyperhomocysteinemia has shown to be associated with number of complications in pregnancy. In the form of IUGR, preterm deliveries, low birth weight, repeated abortions, pregnancy induced hypertension and Abruptio placentae.