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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 12, Issue 1, September 2014 pp 184-189

Research Article

Adenocine deaminase activity in pleural effussion due to various etiologies and its utility as a dignostic tool in tuberculous pleural effusion

Vijaykumar R. Kapse1, Kapil S. More2, Dilip G. Mhaisekar3, Fazullah Hashmi4

1,2Assistant Professor, 3Professor, 4Junior Resident, Department of Pulmonary Medicine, Dr SCGMC, Nanded, Maharashtra, INDIA.

Introduction: To Document ADA activity in Pleural Effusion of Varied Etiologies, This Study was conducted. The Laboratory Technique of ADA level Estimation is a simple Procedure. The Pleural Effussions of Various etiologies are broadly grouped as Tuberculous and Nontuberculous. The Diffrence in ADA levels in these Groups is statistically analysed. Objective: To Compare the ADA activity in Pleural Effussion due to Varied Etiologies and to see its utility in diagnosing TB pleural Effussion. Methodology: This prospective study was undertaken over a period of Two years consisting of 122 adult (age>13yrs) patients of Pleural Effusion with varied etiology. These Patients were divided into three groups as- Group A- Tuberculous Pleural Effusion and Nontuberculous Groups, Group B- Malingnant Pleural Effusion, and Group C-Transudative Pleural Effusion, depending upon Pleural fluid analysis for Biochemistry, Cytology and Microbiology with other relevant investigations like FNAC of lymphnode or lung lesion as required. ADA levels of pleural fluid in all these patients were determined by Gusti and Galantis Calorimetric method. The whole data is collected, tabulated and statistically analysed. Results: In this study, it was observed that, by using ADA cut off value of 60 IU/LIT, Sensitivity, Specificity, Positive predictive value, and Negative predictive value of the test were 77.89%,92.59%,97.39%,54.34% respectively. LR + was found to be 10.52 and LR – was found to be 0.24.

Conclusion: The ADA Level Determination, Probably a good Diagnostic Test with High Specificity for Tuberculous Pleural Effussion.