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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 12, Issue 2, September 2014 pp 332-336
Efficacy of dexmedetomidine infusion of two different doses in patients undergoing laparoscopic surgeries
Tanmay Tiwari1, Rajni Gupta2, Ajay Chaudhary3, Monica Kohli4, Jaishree Bogra5
1Lecturer, Department of Anaesthesia and Critical Care, LLRM Medical College, Meerut, Uttar Pradesh, INDIA.
2,4Professor, 3Associate Professor, 5Professor and HOD, Department of Anaesthesia and Critical Care, KGMU, Lucknow, Uttar Pradesh, INDIA.
Introduction: Dexmedetomidine is an α-adrenoceptor agonist with dose dependent α2-adrenoceptor selectivity. Clinical trials indicate that patients treated with dexmedetomidine required either no additional sedative medication or only small doses of add-on medications. This was significantly different from the add-on medication requirements of patients who did not receive dexmedetomidine. Aims and objectives: to study the Efficacy of dexmedetomidine infusion of two different doses in patients undergoing laparoscopic surgeries. Materials and method: in the present study three groups were compared (control, dex 0.3 and dex 0.6). Sedation using Ramsay sedation score, pain using Visual analogue score (VAS), incidence of post operative nausea and vomiting and use of any drug for pain, vomiting and any other side effect were measured and compared. Results: It was observed that duration of surgery, duration of infusion and use of Fentanyl (μg) was statistically insignificant in all the three groups. The mean time of eye opening in Control, Dex 0.3 and Dex 0.6 was 2.83 ± 0.67 min, 4.35 ± 0.68 min and 4.71 ± 0.61 min respectively. The mean time to follow verbal commands in Control, Dex 0.3 and Dex 0.6 group was 3.32 ± 0.70 min, 4.84 ± 0.68 min and 5.29 ± 0.69 min respectively. The mean time to extubate was maximum (5.94 ± 0.66 min) in Dex 0.6 group as compare to control (3.87 ± 0.62 min) and Dex 0.3 (5.25 ± 0.73 min). The use of antiemetic and analgesics was highest in Control followed by Dex 0.3 and least in Dex 0.6. Conclusion: The perioperative infusion of dexmedetomidine has good efficacy during laparoscopic surgery as it, offered decreased postoperative pain level and better sedation scores, decreased the total amount of analgesic and antiemetics requirements as compared with control. Continuous infusion at 0.3µg/kg/hour is recommended over the 0.6µg/kg/hour.