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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 12, Issue 2, September 2014 pp 375-378
Research Article
Efficacy of allopurinol in decreasing proteinuria and hyperuricemia in Indian patients with type 2 diabetes: prospective, placebo controlled, randomized double blind study

Meeta Amit Burande¹, Amit Burande², Anil Jain³

{¹Professor, Department of Pharmacology} {²Assistant Professor, ³Resident, Department of Anatomy and Diabetic Foot Surgeon}

D Y Patil Medical College, D Y Patil University Kolhapur-416003, Maharashtra, INDIA.

Abstract

Introduction: Diabetic Nephropathy affects up to 30% of the population with ACE-I and ARB as mainstay of treatment but associated with side effect of hyperkalemia. Allopurinol has been studied to reduce the proteinuria in randomized double blind prospective trial for 1 month. Allopurinol has significantly reduced serum uric acid (P = 0.002) and urine protein (P = 0.0003) in study group as compare to control group.