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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 12, Issue 2, September 2014 pp 379-380
Research Article

Bacteriological profile and antibiotic susceptibility pattern of neonatal sepsis at tertiary care hospital in Sangli district of Maharashtra, INDIA: a descriptive study

Haseeb M¹, Khan S T², Shoeb Khan³, Wagh S S⁴, Khaled Badaam⁵

¹Assistant Professor, Department of Paediatrics, MGM Medical College, Aurangabad, Maharashtra, INDIA.

²Professor, ⁵Assistant Professor, Department of Physiology, Government Medical College, Aurangabad, Maharashtra, INDIA.

³MBBS, Government Medical College, Aurangabad, Maharashtra, INDIA.

⁴Professor and Head, Department of Paediatrics, Government Medical College, Miraj, Maharashtra, INDIA.

Abstract

Neonatal sepsis remains a significant cause of morbidity and mortality in newborns, more so in developing countries like India due to delivery and post natal care taking place in an unclean environment having more chances of contamination with infective organisms. For the effective treatment of sepsis it is essential to have periodic review regarding the causative organisms and its susceptibility to available antibiotics.  Present study was undertaken to describe the bacteriological profile and antibiotic susceptibility pattern of culture isolates from Neonatal sepsis patients at a tertiary care centre in Sangli district of Maharashtra, India. Study was carried over a period of one year at the Department of Paediatrics of PVPGH Sangli and Govt Medical College, Miraj. One hundred and five neonates (0 to 28 days) with clinical diagnosis of sepsis were included in the study. Patients who underwent surgery and those who were older than 28 days were excluded. Blood culture reports were studied in 105 cases of clinically suspected septicaemia in neonates using the standard technique of Mackie and McCartney. The antibiotic sensitivity was performed by Kirby-Bauer's disc diffusion method. Blood culture was positive in 19 cases (18.09%). Klebsiella pneumoniae and staphylococcus aureus were the most common isolated organisms. Resistance to antibiotics was very common in isolated organisms. Gram positive organisms isolated were found to be sensitive to ciprofloxacin, amikacin, chloramphenicol and gram negative organisms were found to be sensitive to vancomycin.