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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 12, Issue 2, September 2014 pp 417-419

Research Article

Lipid profile and homocysteine levels in patients with chronic periodontitis with and without cardiovascular disease

Madhur M Gupta1, Suresh N Chari2, Abhay P Kolte3

1Professor and Head, 2Professor, Department of Biochemistry, NKP Salve Institute of Medical Sciences, Hingna, Digdoh hills, Nagpur– 440019, Maharashtra, INDIA.

3Professor and Head, Department of Periodontitis, VSPM Dental College, Nagpur, Maharashtra, INDIA.



Introduction: Common risk factors such as smoking, diabetes, hyperlipidemia, aging and male gender place an individual at risk for both periodontitis as well as cardiovascular disease. A Case control study was carried out in 50 subjects with chronic periodontitis aged 30-65 years (group II) and age matched with 50 control subjects (group I) .Group III (n=30) patients included patients of periodontitis with cardiovascular disease (CVD) and group IV(n=40) included patients with cardiovascular disease. Blood samples collected was assessed for lipid profile and homocysteine levels. Total cholesterol, LDL-cholesterol, triglycerides and homocysteine are significantly increased (p<0.001) in periodontitis patients with and without CVD and patients with CVD when compared with normal healthy controls. Significant positive correlation was found when total cholesterol and triglycerides are compared with homocysteine in periodontitis with and without CVD and patients with CVD alone. Hence, homocysteine assessment is useful in predicting the future risk of cardiovascular disease in chronic periodontitis patients