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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 14, Issue 3, April 2015 pp 559-562

Research Article

Role of crush cytology in the intraoperative diagnosis of meningioma

Krishna Prasad HV1, Fernandes H2, Nayak TM3

{1Junior Resident, 2Professor and Head, Department of Pathology} {3Associate Professor, Department of Neurosurgery}

Fr Muller Medical College, Mangalore, Karnataka, INDIA.

Background: Primarytumours of central nervous system constitutes less than 2 % of overall cancers in adults. Meningiomas form 24-30% of primary intracranial tumours. The crush/squash smear cytology acts as prelude for intraoperative neurosurgical consultation. It guides the neurosurgeon for lesion targeting and surgical resection. Objective: To assess the accuracy and utility of cytomorphological evaluation of meningiomas by crush/squash cytology and subsequent correlation with histopathology. Materials and Methods: This was both a retrospective and prosspectivestudy of elevenradiologically and clinically suspected meningiomas sent for intraoperative consultation by squash cytology. The biopsy specimens of these cases sent in normal saline were smeared and stained with toluidine blue and Hematoxylin and Eosin stain(HandE).The cytomorphological features of these tumours was then studied and correlated with histopathological sections. Results: Of the eleven cases of meningiomas we observed a slight female predilection with male to female ratio of 1:1.2.These tumours were more common in the age group of 41-60 yrs(6/11) followed by second peak in 61-80 yrs(3/11) and two cases between 20 to40 yrs. Most common location of these tumours was cerebrum(6/11=55%) followed by cerebellopontine angle and posterior fossa(4/11=36%) and one in sellarlocation. Cytological and histological correlation was achieved in all the 11 cases with 100% correlation. Conclusions: Crush preparation is fairly accurate, relatively safe rapid, simple, easily reproducible and cost effective tool to diagnose meningiomas.