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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 14, Issue 3, April 2015 pp 573-577

Research Article

Thyroid dysfunction in type-2 diabetes mellitus

Mohd Vaseem Akram1, Ashish Mittal2, Kaushal Kishore3

1,2PG Student, 3Professor and HOD, Department of General Medicine, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, INDIA.

Type- 2 Diabetes Mellitus is a growing metabolic disorder worldwide. Approx 20% population in South Asian region suffer from type-2 Diabetes Mellitus and India is said to be the diabetic capital of world. Thyroid disorder is the commonest endocrine disorder, yet not much is known about the impact or association of type-2 Diabetes Mellitus on Thyroid dysfunction. The present study was done to find out the frequency and type of Thyroid dysfunction among type-2 Diabetes Mellitus patients. Study design: A population based prospective study was done over 11/2 years at Santosh Hospital, Ghaziabad. 1000 patients of both gender of type-2 Diabetes Mellitus were included in the study after getting formal consent and ethical clearance. Inclusion Criteria: Patients having FPG ≥ 7 nmol/ l ( ≥ 126 mg / dl ), PPBG ≥ 11.1 nmol/l ( ≥ 200 mg / dl ), Random BG ≥ 11.1 nmol/l ( ≥ 200 mg / dl ) Exclusion Criteria: Patients with type-2 Diabetes Mellitus, Gestational DM, steroid induced DM, and DM with complication were not included in the study. Result: Out of 1000 patients of type-2 Diabetes Mellitus, 333 patients had abnormal Thyroid profile, overall prevalence of thyroid dysfunction was 33.3% with subclinical hypothyroidism 11.1%, Hypothyroidism 14.4%, Hyperthyroidism 2.9% and subclinical Hyperthyroidism 4.9%. In the age group 60-69 years, prevalence of dysfunction was 10.6%. Maximum number of hypothyroid cases (n – 86) were seen in patients with blood sugar 200- 249 mg/ dl. Conclusion: The prevalence of Thyroid dysfunction in type-2 Diabetes Mellitus was substantially higher (33.3%) in the present study. In view of the high prevalence of Thyroid dysfunction in type-2 Diabetes Mellitus, we recommend screening of all patients with type-2 Diabetes Mellitus for Thyroid dysfunction.