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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 14, Issue 3, April 2015 pp 605-609
Study of serum hsCRP and lipid profile in pre-eclampsia
Vijayalakshmi P1, Usha S M R2, H V Shetty3, Priyadarshini K S4, Victoria ksh5, Montey Naruka6
1,5,6Post graduate and Tutor, 3HOD and Professor, 2,4 Professor, Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, INDIA.
Objectives: The aim of the study is to determine the role of serum hsCRP as a pro inflammatory marker in preeclampsia and to evaluate the role of serum lipids (T.Cholesterol,non HDL, Triglycerides) in the pathogenesis of preeclampsia, as because the reports on lipid abnormalities in preeclampsia were inconsistent. Materials and method: It is a cross sectional study conducted in the Department of Biochemistry, RRMCH. The study group includes 50 preeclamptic women and age matched (18-35years) 50 healthy pregnant women. Study group were selected according to inclusion and exclusion criteria. Fasting blood samples were collected to perform serum hsCRP, T. Cholesterol, Triglyceride, and non HDL as calculated according to formula (T cholesterol-HDL C). Results: The data was analyzed using students t test, p value of <0.05 considered statistically significant. The mean value of serum hsCRP was statistically significant with p value<0.0001 ie values high in cases when compared with controls. Expect LDL other parameters like T. Cholesterol, Non HDL, Triglycerides were statistically significant (p value0.0001) with values being high in preeclamptic groups than in healthy pregnant women. HDL values were less in the case group than in control group. Conclusion: The significantly high levels of serum hsCRP in preeclampsia could be due to an exaggerated systemic inflammation which could be a marker of pathological uteroplacental perfusion, a characteristic feature of preeclampsia. Abnormal lipid profiles may have a role in promotion of oxidative stress and maternal endothelial dysfunction which is a classic hallmark of preeclampsia. Hence early detection of these parameters may aid in better management, providing a better maternal and fetal outcome.