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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 14, Issue 3, April 2015 pp 507-509

Research Article

Study of combination of mifepristone and misoprostol in termination of pregnancy upto 63 days

Raghunath Shinde1, Rahul Shah2, Sudhir S Bhave3

1Assistant Professor, 2Junior Resident, 3Professor and HOD, Department of OBGY, Bharati Hospital, Sangli, Maharashtra, INDIA.

Introduction: Study was carried out to know the efficacy, safety, and adverse effects of medical termination of pregnancy with the use of drugs like mifepristone and misoprostol. They were administred orally and per vaginally respectively in pregnancy upto 63 days pregnancy were confirmed by clinical and USG examination. Methods: 50 cases willing for undergoing medical abortions fulfilling the inclusion criteria were selected. On day one, 200 mg of Mifepristone was given orally with water. On day three, 400 mcg of Misoprostol were kept per vaginally. Patients were observed for 4 hr to know the response of the drugs like P/V bleeding, lower abdominal pain andbackache. If there is no response observed then addition dose of 400 mcg Misoprostol kept Per vaginally. Patient discharge on 4th day and asked her to follow up after two weeks to confirmed the completion of abortion by USG pelvis. Results: Completion of abortion rate in women with amenorrhoea near or less than 49 days is 95% versus 63 days is 93.34%. Women with induction abortion interval within 4 hr. in two group were 95% and 93.34% respectively. The success rate at the end of 14th days in group A is 95% and in group B is 93.34%. Conclusion: As this regimen is non invasive and cost effective more acceptable by the patient who are coming for termination of pregnancy. Medical abortion with the Misoprostol 200 mg and 400 mg on Day 1 and 3 was carried out to demonstrate that combination of Mifepristone andMisoprostol can be effective and safe regimen upto 63 days of pregnancy.