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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 1, May 2015 pp 41-46

Research Article

Exploring ototoxicity of aminoglycosides

B G Patil1, Alka B Patil2

{1Professor, Department of ENT} {2Professor and HOD, Department of OBGY} ACPM Medical College, Dhule, Maharashtra, INDIA.

Any drug with potential to cause toxic reactions to structures of the inner ear, including the cochlea, vestibuler, semicircular canals, is considered ototoxic. The evidence for the ototoxicity of aminoglycoside antibiotics is overwhelming. Drug induced damage to the structures of the auditory and balance system can result in hearing loss, tinnitus and disequibrium. Fetal ototoxicity have been described after maternal exposure to aminoglycoside toxicity, are evaluated. There is susceptibility and genetic predisposition for Aminoglycoside ototoxicity. Relative oxygen species (ROS) participate in the cellular events leading to aminoglycoside induced hearing loss. Monitoring and challenges to hearing loss discussed. Prevention and future prospects explored.