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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 1, May 2015 pp 28-30

Research Article

The role of thrombocytopenia in the clinical course of leptospiral infection

Linda Rose Jose1, M N Sumana2

1Research Scholar, 2Professor, Department of Microbiology, JSS Medical College and Hospital, Mysore, Karnataka, INDIA.

Aim: This study is aimed to find out the incidence of thrombocytopenia in leptospirosis patients and to correlate thrombocytopenia with other parameters like hepatorenal failure, lung involvement and bleeding manifestations. Material and Methods: This study was conducted at Department of Microbiology, JSS Medical College and Hospital, Mysore, India from September 2014 to February 2015. Ethical approval was obtained from the Institutional Ethics Committee. The medical records of all serologically confirmed leptospirosis patients were retrospectively reviewed. Thrombocytopenia was then categorized as mild, moderate and severe and then correlated with renal dysfunction, hepatic dysfunction and haemorrhagic manifestations along with the course of infection. Results: A total of 60 patients were serologically positive for leptospirosis during this study period. Thrombocytopenia was observed in 52/60 cases, bleeding manifestations were seen in11, 43 had hepatic failure, 22 had renal failure. Conclusion: Thrombocytopenia in patients with Pyrexia of Unknown Origin (PUO) should alert physicians to the differential diagnosis of leptospiral infection and prompt the institution of appropriate therapy. It is important to recognize thrombocytopenia early in the course of leptospirosis so that appropriate steps can be taken to prevent further complications associated with thrombocytopenia in such patients.