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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 15, Issue 2, June 2015 pp 310-312
Research Article
A biochemical study on scenario of extracellular sodium and potassium in patients with psoriasis-Altered membrane permeability to potassium
M Jansirani Sivasubramanian1, R Hemavathi Baskar2, Abirami Soundarajan3, A Bunaratchagan4
{1Professor, Department of Biochemistry} {4Assistant Professor, Department of Dermatology}
Sri Lakshmi Narayana institute of Medical Sciences,Puducherry-605502, INDIA.
2Assistant Professor, Department of Physiology, Vellore Medical College, Vellore District. Tamil Nadu, INDIA.
3Department of Anesthesialogy, Madras Medical College, Chennai, Tamil Nadu, INDIA.
Abstract
Objective: To quanitate the serum sodium and potassium in patients with psoriasis and to identify the probable cause of hyperkalemia in psoriasis. Introduction: The pathologic process is likely due to dysregulation of activated T-cell interactions with antigen presenting cells and overproduction of inflammatory cytokines such as interferon-α and tumor necrosis factor-alpha. Methodology: 24 psoriatic patients on first presentation at dermatology OPD were included in this small pilot study. The blood samples were analysed for the serum electrolytes namely sodium and potassium were analysed by the Ion selective electrode method adopted in the automated computerised electrolyte analyser. Any other disorders which also lead to hyperkalemia were not considered Results and Discussion: The obtained data was analysed by student ‘t’ test. Sodium (P< 0.001) and Potassium (P< 0.001) were statistically significant. This present study shows that, there was significant elevation of potassium ion in patients with psoriasis. This suggests that it might due to the Na/K ATPase pump activity. Conclusion: Alteration in the activity of Na+ and K+ pump or Na-K-co transport might be the cause which needs further study.
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