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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 2, June 2015 pp 313-317

Research Article

A study of autonomic functions in patients with iron deficiency anaemia

Brinda Venkatraman1, Prasad A Udhoji2, Yogesh G Patle3

1Professor and HOD, 2Assistant Professor, Department of Physiology, Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai-400008, Maharashtra, INDIA.

3Assistant Professor, Department of Pathology, Peoples College of Medical Sciences and Research Centre, Bhopal-462037, Madhya Pradesh, INDIA.

Background and Objectives: Iron deficiency anaemia (IDA) is possibly a most common nutritional disorder having widespread occurrence throughout the world. Anaemia has been associated with various cardiovascular outcomes such as left ventricular dysfunction, cardiomyopathy etc. along with increasing morbidity and mortality. Since most of the physiological alterations occuring in chronic anaemic states are cardiovascular in nature and autonomic nervous system (ANS) has a major role to play in all cardiovascular adjustments, intactness of normal functioning of ANS is of importance. Our objective was to study the integrity of ANS in chronic IDA using standard tests for autonomic functions, to compare autonomic functions in IDA patients with normal controls, and to infer whether IDA of more than 6 months duration with Hb levels of less than 10 gm% shows any dysfunction in autonomic machinery and to explore the possible causes of dysfunction. Methods: 30 anaemic patients with Hb < 10 gm% and 30 normal controls were included in study. Their hemoglobin levels were determined and standard tests to determine autonomic functions (Resting HR and BP, Expiration – Inspiration ratio, Postural tachycardia index, Valsalva ratio, sustained hand grip and cold pressor tests,) were carried out in them. Results: Statistical evaluation was done using unpaired ‘t’ test. Except for Resting HR and Expiration – Inspiration ratio, other autonomic function tests showed statistically significant difference between the patients and controls (p<0.05) Interpretation and Conclusion: Chronic anaemia impairs the integrity of ANS and the blunted baroreceptor and chemoreceptor response may be responsible for its causation.