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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 3, July 2015 pp 473-475

Research Article

Clinical study of enteric fever at a tertiary care centre

Rakesh Thakuriya1, Eshan Sharma2, Sanjeev Thaural3

1,2Assistant Professor, 3 Jr. Resident, Department of Medicine, N.I.M.S Medical College and Hospital, Jaipur, Rajasthan, INDIA.

Background: Enteric fever remains a serious public-health related problem in the developing countries. Salmonella typhi and Salmonella paratyphi A have demonstrated a changing antibiotic susceptibility pattern and also there is an emergence of multi drug resistant strains. Objective: Present study was done to study and evaluate the clinical profile and antibiotic response among typhoid fever cases in a tertiary care setting. Methods: It is a retrospective study of adult typhoid fever patients done at our tertiary care centre over a period of one year. Diagnosis of patients was done on the basis of clinical presentation, Widal test and blood culture. Blood culture samples were collected from suspected enteric fever patients and tested microbiologically by standard procedure. Antibiotic susceptibility test was performed by Kirby-Bauer disc diffusion method and results were interpreted by National Committee for Clinical Laboratory (NCCLS) guideline. The sensitivity pattern of the blood culture was noted. The mode of presentation, response to antibiotic therapy, complications and duration of hospital stay were recorded. Defervescence was defined as the number of days required for abatement of fever after starting the antibiotics. Results and Conclusion: The study comprised of 55 patients and their records were evaluated, 44 study subjects were males and 11 study subjects were females. Fever was the most common symptom and was present in all the patients. Headache was present in 31 (56.4%) patients and generalized body ache was present in 26 (47.3%) patients while Splenomegaly in 21 (38.2%) patients and hepatomegaly in 20 (36.4%) patients were the common presenting clinical signs. The average duration of hospital stay was 7.9 days. A maximum sensitivity of 98.2% was observed with ceftriaxone, whereas resistance to ciprofloxacin was common (20 %). The outcome was favourable with 52 (94.5%) patients recovering from the illness. Relapse of the disease was seen among three (5.45%) patients.