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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 3, July 2015 pp 479-482

Research Article

Study of mycobacterium culture and sensitivity pattern of various anti-tubercular drugs in suspected multidrug resistant tuberculosis patients

Hafiz Deshmukh1, Ashish Deshmukh2, Sunil Jadhav3, Shivprasad Kasat4, Sandeep Dandin5, Rohit Singh6

1,4Assistant Professor, 2Professor and HOD, 3Associate Professor, 5,6Resident, Department of Pulmonary Medicine

MGM Medical College and Research Centre, N-6 CIDCO, Aurangabad, Maharashtra, INDIA.

Resistance to the first line drugs is the most difficult part of treating tuberculosis. Different studies have found upto 3% previously treated patient and Upto 17% patients who have taken Antitubercular treatment previously as being multidrug resistant MDR TB(Multi drug resistant tuberculosis) is defined as resistance to isoniazid and rifampicin. More and more patients are attending chest OPDs with pulmonary. tuberculosis and not responding to primary line of antituberculosis drugs. We undertook a study in our institution to find the drug susceptibility pattern in 50 patients who were suspected to be MDR (resistant to INH + Rifampicin) and found only 2% of such patients to be sensitive to both INH and RFM (i.e. 98% were MDR-TB patient),no patient was sensitive to all the first line drugs,21patients(42%)were sensitive to only one first line drug and 4% patients sensitive to only one drug cycloserine. Our study endeavoured to find the sensitivity and resistance patterns of the mycobacterium to the various antituberculous drugs. This study will be useful in identifying and choosing which drugs are more effective in management of MDR Tuberculosis. Abbreviation: MDR: Multi Drug resistant Short Running Head: Drug Sensitivity pattern in M.D.R Tuberculosis