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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 15, Issue 3, July 2015 pp 497-500
Comparison of Inflammatory and Antioxidant status in lean and obese type 2 Diabetes Mellitus Patients
Cherekar Laxmikant Narayanrao1, Bardapurkar J S2, Asegaonkar S B3, Thorat A P4
1Assistant Professor, 3Associate Professor, 4Professor and Head, Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, INDIA.
4Professor and head, Department of Biochemistry, Institute of Medical Sciences, Badnapur, Jalna, Maharashtra, INDIA.
Objectives: Recent studies suggest that low grade systemic inflammation and oxidative stress is present among patients at high risk for atherothrombotic diseases. So we decided to investigate serum C reactive protein (CRP) as a marker of systemic inflammation and serum super oxide dismutase (SOD) as a marker of free radical activity in metabolic syndrome patients, obese Type II diabetes mellitus (T2DM) (BMI > 30). Materials and Methods: Total 102 subjects in age group 40-70 years were studied and divided as group I - (n=34) healthy controls (BMI < 25), Group II- (n= 34) diabetic patients (BMI <25), Group III – (n=34) metabolic syndrome patients, obese T2DM (BMI >30). In all these subjects BMI, CRP (latex agglutination), SOD (marklund and marklund method) were measured. Results: Mean CRP was 2.3+/-0.2 µg/ml and significantly raised in group III as compared to Group II (0 µg/ml) and Group I (0 µg/ml) (p< 0.001).Increased CRP was associated with high BMI (p<0.001). Mean SOD was 1.32+/-0.21 units/ml in group III as compared to group II (2.44+/- 0.09unis/ml) and group I (3.46+/-0.08 units/ml) (p<0.001). Decreased SOD was associated with high BMI (p < 0.001). Conclusion: We found significant association between increased CRP levels and decreased SOD with high BMI in metabolic syndrome patients, obese T2DM (BMI > 30) group III as compared to group II and group I. Thus these data further supports the hypothesis that CRP may serve as an inflammatory marker for underlying atherosclerosis and low levels of SOD suggests increased free radical activity in group III, predicting risk of coronary heart disease.