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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 15, Issue 3, July 2015 pp 510-514
Role of HSP 90 alpha in oral lichen planus: An immunohistochemical evaluation
A Soumya1, N Malathi2, D Prathiba3, S Anandan4, Satha Sivasubramaniam5
1Senior Research fellow, 2,5HOD, 3Professor, 4Dean, Department of Oral Pathology and Microbiology, Faculty of Dental sciences,
Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, INDIA.
Background: Intracellular homeostasis is maintained by the molecular chaperones through protein folding and stabilization of other proteins. The proteome against the misfolded protein and aggregation are guarded by the molecular chaperones. They are also critical for the survival of cells that undergo stress due to these misfolded proteins. The current immunohistochemical study was conducted to unravel the expression pattern of Heat shock protein 90. Aim: To evaluate and compare the immunohistochemical pattern of expression of Heat shock protein 90 alpha with various clinical and histological parameters of Oral lichen planus and Oral squamous cell carcinoma. Materials and Methods: Archival tissues from the department of oral pathology were retrieved. The cases based on histopathological diagnosis were chosen. The immunohistochemistry kit containing monoclonal anti HSP 90 alpha was purchased and the procedure was performed in the department lab. The samples distribution was 8/31 normal and 23/31 Oral lichen planus. Heat shock protein 90 alpha was assessed on basis of percentage of cells and intensity of staining. Results: Overall, our study indicates that Heat shock protein 90 alpha expression in normal oral mucosa was mild, with increase in expression in Oral lichen planus. The results were statistically significant with a p- value of 0.000 Conclusion: This study brings out the importance of Heat shock protein 90 in oral tumorigenesis and malignant transformation. These finding defines Heat shock protein 90 as a marker protein for risk assessment in malignant transformation of oral lichen planus.