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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 15, Issue 3, July 2015 pp 538-541
Sarcomatoid renal cell carcinoma: A case series
K Subashree1, M Susruthan2, N Priyathersini3, Leena Dennis Joseph4, Sandhya Sundaram5
1PG Student, 2,3Assistant Professor, 4,5Professor, Department of Pathology, Sri Ramachandra Medical College and Research Institute
Porur, Chennai-116, Tamil Nadu, INDIA.
Introduction: Renal cell carcinoma is the most common form of Renal malignancy. Sarcomatoid renal cell carcinoma represents a high grade dedifferentiation of Renal cell carcinoma. This phenotype can occur in all subtypes of renal cell carcinomas, including clear cell, papillary, chromophobe, and collecting duct carcinoma. Although prognosis in sarcomatoid renal cell carcinoma is known to be extremely poor, little is known about the clinicopathologic information about them. Methods and Methodology: The population of this retrospective study consisted of all patients who underwent surgery for Renal cell carcinoma between January 2010 and February 2013 in the Department of Pathology, Sri Ramachandra university and Research Institute .A total of 64 renal cell carcinoma cases were diagnosed among which 9 had sarcomatoid changes. All 9 cases were reassessed and the diagnosis was confirmed on the basis of morphologic features. Complete baseline and follow-up data were available for analysis for all 9 patients. Conclusion: Present study showed that sarcomatoid changes were seen more commonly in younger age group with male preponderance and necrosis was a consistent feature. Sarcomatoid areas constitute 1-25% in majority of cases which makes extensive sampling an important measure. Majority of renal cell carcinomas with sarcomatoid changes have a high grade and high stage. Identification of sarcomatoid areas in renal cell carcinoma is of prime significance as it has prognostic implications.