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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 3, July 2015 pp 606-609

Research Article

Profile of myelodysplastic syndrome: A study done at tertiary care centre from south India

Rithika Rajendran¹, Sai Shalini C N¹, D Febe R Suman¹^*, Krishnarathnam K², Rashmika Rajendran³, Teena Koshy⁴, Suresh S⁵

¹Department of Pathology, ²Department of Hematology, ³CRRI, ⁴Department of Human Genetics, ⁵Department of Medical Oncology

Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, INDIA.

Abstract
Introduction: Prognosis of myelodysplastic syndrome (MDS) depends on the cytogenetic profile, blast percentage and cytopenias. This study was intended to categorize MDS patients according to established classifications, scoring systems and to assess mortality, acute myeloid leukemia (AML) transformation and survival. Materials and Methods: This is a retrospective cohort study done on 26 completely evaluated and followed up adult de novo MDS patients from July 2009 to June 2015. The demography, hematological profile, classification according to WHO, International Prognostic Scoring System (IPSS) and IPSS-R (Revised) were retrieved from records after ethics committee approval. The results were tabulated in Microsoft Excel and statistically analyzed. Results: Male/female ratio was 1.2:1. Females were younger. AML transformation and mortality were high with RAEB-1, RAEB-2, IPSS >2.5 and IPSS-R >6. Comparable with other Indian studies, 53.8% had cytogenetic aberrations of which 21.4% had complex abnormalities. 65.4% were of good prognostic subgroup. Mortality was high in the very poor cytogenetic group. Conclusion: AML transformation and mortality were comparable with existing literature. Rare cytogenetic abnormalities of t (5; 17) and t (8; 16) seen can be predictors of leukemia. This study will help in adding to the MDS database as minimal data is available for Indian population.