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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 15, Issue 3, July 2015 pp 638-642
Study of serum uric acid activity in dyslipidemia
Jaba Chauhan1, Virendra Verma2, Kaushal Kishore3
1,2PG IInd Year, 3Professor and Head, Department of Medicine, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, INDIA.
With increasing prevalence of obesity, hypertension, diabetes mellitus, dylipidemia in the general population due to lifestyle changes, the risk for heart disease, renal disease and cerebrovascular accidents is on the rise. While the topicality of serum uric acid being a risk factor is currently controversial, there is little controversy regarding its association with cardiovascular and renal disease, especially in patients with hypertension, diabetes mellitus and dyslipidemia. The risk for heart failure increases by 21% in patients with hyperuricemia, by 47% in patients with dyslipidemia, and by almost 78% in patients with both hyperuricemia and dyslipidemia. Aim: The aim of this study is to evaluate the association between dyslipidemia and hyperuricemia. Methodology: The study was conducted as a case control study. The patients attending the OPD of Medicine department of Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh are included in this study, during a period of July 2014 to June 2015. A written informed consent was taken from the patients inducted into the study. A copy of patient information sheet was also given to the patient, and ethical clearance was taken. Result: In the present study, we found 50% of males and 50% of females in cases, and 46% males and 54% females in controls. Hyperuricemia, which is defined as serum uric acid levels of >7 mg/dl in males and >6 mg/dl in females is frequently associated with dyslipidemia. However no consensus has been reached if hyperuricemia in dyslipidemia is a secondary phenomenon or whether hyperuricemia predicts the development of dyslipidemia. Summary: The prevalence of obesity, hypertension, diabetes mellitus, dyslipidemia and hyperuricemia has been increasing over the last few decades due to rising living standards with modernisation and urbanisation. Dyslipidemia and hyperuricemia are both individual risk factors for cardiovascular and cerebrovascular diseases. The risk for these increases many fold when both these factors are present in a patient. Conclusion: Our study has shown that uric acid elevation is an important component of dyslipidemia. Measuring uric acid is a useful test for a clinician, as it carries important prognostic information. An elevation of uric acid is associated with an increased risk for cardiovascular disease and mortality.