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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 15, Issue 3, July 2015 pp 451-454

Research Article

Study of urinary microalbumin/creatinine levels and ratio in gestational hypertensive patients

Swapna V S1, Jambale triveni A2, Jayaprakash Murthy D S3

1Assistant Professor, Department Of Biochemistry, Viswabharathi Medical College, Kurnool, Andhra Pradesh, INDIA.

2Department of Biochemistry, Gadag Institute of Medical Sciences, Gadag, Karnataka, INDIA.

3Department of Biochemistry, Oxford Medical College, Bangalore, Karnataka, INDIA.

Background: Gestational hypertension (BP>140/90mmHg) or pregnancy induced hypertension usually precedes pre-eclampsia (BP>140/90mmHg associated with proteniuria). Many tests to predict pre-eclampsia are coming up on the horizon. microalbuminuria are one such tests to predict pre-eclampsia which may be present before other clinical signs and symptoms. AIM: To determine urinary microalbumin, urinary creatinine and urinary microalbumin/creatinine ratio in pregnancy induced hypertension and in normal pregnant women. Material and Methods: The study included 100 subjects with gestational age between 24-38weeks and divided into two groups viz. control group and study group. The control group included 50 subjects who were normal pregnant women and study group included 50 subjects who were gestational hypertensive patients. The urinary creatinine was estimated by Jaffe’s method and urinary microalbumin was estimated by Turbidimetric Immunoassay (AGAPEE company) in all the subjects. Results: The estimated mean levels (mean ± SD) of urinary microalbumin, creatinine in control group were 28.1 ±25.1, 0.95 ±0.16 respectively and in patients with gestational hypertension they were 157.8 ±48.7, 1.21 ±0.37 respectively. The statistical analysis by unpaired t-test shows that the levels of urinary microalbumin were significantly increased (p<0.001) and the urinary creatinine were significantly increased (p < 0.001) in gestational hypertensive patients when compared to healthy controls. The mean urinary microalbumin/creatinine ratio in control group were 0.06±0.05 and in gestational hypertensive patients were 0.21 ±0.08. Thestatistical analysis by unpaired t-test shows that the levels of urinary microalbumin/creatinine ratio were significantly increased (p<0.001) in gestational hypertensive patients when compared to healthy controls. Conclusion: This study suggests that a regular evaluation of urinary microalbumin/creatinine ratio after 20wks of gestation may be an effective screening method for impending pre-eclampsia and may identify population at risk to be included in primary prevention programmes.