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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109
Volume 16, Issue 1, Aug 2015 pp 01-06
Sympathetic cardiovascular function integrity in children with parental history of diabetes mellitus
Amruta Nitin Kumbhar1, Lalit H Nikam2
1Assistant Professor, Department of Physiology, D Y Patil Medical College, Kolhapur, Maharashtra, INDIA.
2Associate Professor, Department of Physiology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, INDIA.
Introduction: Type 2 DM has a strong genetic component. Individuals having parents with type 2 DM have an increased risk of diabetes; if both parents have type 2 DM, the risk approaches 40%. The autonomic nervous system regulates the electrical and contractile activity of myocardium via interplay of sympathetic and parasympathetic activity. Sympathetic nerves of heart are derived from the upper thoracic 5 segments of the spinal cord. In general, sympathetic stimulation increases the overall activity of the heart. This is accomplished by increasing both the rate and force of heart contraction. Amis and Objectives: To study Sympathetic cardiovascular Function Integrity in children with parental history of diabetes mellitus. Materials and Method: The study procedure was carried out on healthy volunteer medical students of age group 18 to 25 years. They were first categorized into two groups, control (without parental history of diabetes mellitus) and subject (with parental history of diabetes mellitus) .The sample size was 70 in the control group and 70 in the subject group. All participants were examined after explaining the study procedure. The cardiovascular tests to measure cardiovascular autonomic response were performed. These tests were explained and demonstrated to the participants before performing on them. Tests Done For Assessing Sympathetic Activity were Blood pressure response to standing (Orthostasis) test, Hand grip test and QTc interval test. The mean and standard deviation (S D) was calculated for all the parameters. The data was entered using Microsoft Excel (2007). Statistical analysis was done using SPSS version 10.The statistical test used were (as per the requirement of the data). Results: The age distribution and sex distribution was nearly same in the study and control group. Mean resting pulse, mean SBP and DBP was slightly more in study group as compared to control group and the difference was not significant statistically. While assessing sympathetic activity Orthostasis and Mean QTc interval test showed no statistically significant difference in study and control group whereas sustained handgrip test showed statistically significant difference in study and control group. Conclusion: Early subclinical sympathetic autonomic neuropathy may develop in children of type 2 diabetic parents without the presence of long term hyperglycemia. It could be due to inherited susceptibility genes for sympathetic autonomic neuropathy which could be expressed before or even without development of diabetes mellitus.