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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 16, Issue 1, Aug 2015 pp 79-82

Research Article

Evaluation of lipid profile in patients with liver cirrhosis and their association with severity of the disease

Vijay laxmi Nangliya1, Anjali Sharma1, Shyam Sunder3, Dharamveer Yadav1, Sandeep Nijhawan2, Sandhya Mishra1

1Department of Biochemistry, 2Department of Gastroenterology, SMS Medical College Jaipur Rajasthan and Institute of Liver and Biliary 3Science, New Delhi, INDIA.

The study was conducted to determine the Lipid profiles in Patients with Liver Cirrhosis and to assess their association with severity of the disease. In an analytical cross sectional study, 150 Cirrhotic subjects of either sex ranging in age from 25-65 years were included in the study and the results were compared with 50, age and sex matched healthy control subjects. All Cirrhotic subjects were assessed for severity of disease as Mild (Child A), Moderate (Child B) and Severe (Child C) as per Child Pugh classification. Total Cholesterol, HDL, LDL and triglycerides were measured. The results of this study showed that all the serum lipid profile parameters (Total Cholesterol, LDL and HDL) were significantly (p <0.05)decreased in cirrhotics as compared to control group and the concentration of these study variables decreased with Severity of liver disease and the mean level difference was statistically significantly (p <0.01) with the exception of serum triglyceride levels. Triglyceride levels rather showed a decline in Cirrhotic patients but it was not statistically significant. Dyslipidemia exists in patients with liver cirrhosis. Serum Lipid profile is routinely measured parameters, which may have independent prognostic value in patients with liver cirrhosis thus assessment of the serum lipid profile is important for an effective treatment and prognostic evaluation of patients with chronic liver disease.