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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 16, Issue 1, Aug 2015 pp 10-12

Research Article

Study of Glutathione S-Transferase in gastrointestinal cancer

N R Hazari¹, V S Hatolkar²

¹Associate Professor, Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, INDIA.

²Professor, Department of Biochemistry, M.G.M. Medical College, Aurangabad, Maharashtra, INDIA.

Abstract
Glutathione S-Transferase(GST) distributed widely in tissues such as liver, lung, skin, brain, intestine and placenta. Levels of enzyme detection in serum are useful for diagnosis and prognosis of human disease. Recently GST may be useful in monitoring pathogenesis of liver disease. In the present study of serum GST was significantly higher in patients with esophagus and stomach cancer as compared to those obtained from normal healthy group. Our results showed a significant increased activity of GST in stage III patients than stage II patients of both cancers; which may trigger the progression of cancer.