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International Journal of Recent Trends in Science and Technology, ISSN 2277-2812 E-ISSN: 2249-8109

Volume 16, Issue 1, Aug 2015 pp 129-132

Research Article

A study of ondansetron alone and ondansetron plus dexamethasone for prevention of nausea and vomiting after post-tympanoplasty under local anesthesia

Shashikant Dorkar1, Rajesh Navale2, Vikas Kumar3

{1Associate Professor, Department of ENT} {2SR, 3PG Student, Department of Anaesthesia}

Bharati Vidyapeeth Medical College and Hospital, Sangli, Wanlesswadi, Sangli-Miraj road, Sangli - 416414, Maharashtra, INDIA.

Introduction: Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (PONV). These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing tympanoplasty. The aim of this study was to compare the effect of intravenous ondansetron and ondansetron with dexamethasone on post-tympanoplasty PONV. Methods: In a double-blind randomized controlled clinical trial, 300 patients were divided into two groups including one receiving ondansetron, one receiving ondansetron plus dexamethazone. All patients were subjected to tympanoplasty. The patients in the first group received ondansetron (4 mg IV), second group received ondansetron (4mg) with dexamethasone (8 mg) prior to infiltration of local anesthesia. Using Bellivelles scoring system, the incidence of PONV and its severity during the 24-hour period after surgery were measured and compared. Results: There was no significant difference among PONV in the two groups in the first two hours after the surgery. However, in 2-8, 8-16 and 16-24 hours after the surgery the PONV in ondansetron with dexamethasone groups were significantly lower than ondansetron group. Conclusion: Ondansetron with dexamethasone were more effective than ondansetron in controlling PONV after tympanoplasty surgeries. Moreover, ondansetron with dexamethasone was more effective than ondansetron in preventing PONV.